Abstract #4518
Alteration of White Matter Networks in Unilateral Mesial Temporal Sclerosis Identified by The Whole Brain Tract-Based Automatic Analysis
Yao-Chia Shih 1,2 , Yun-Chin Hsu 2 , Horng-Huei Liu 3 , and Wen-Yih Isaac Tseng 2
1
Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taipei, Taiwan,
2
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taipei, Taiwan,
3
Department
of Neurology, National Taiwan University Hospital,
Taipei, Taipei, Taiwan
Patients with unilateral mesial temporal sclerosis(MTS)
were shown to have extensive gray matter (GM) and white
matter (WM) abnormalities ipsilateral and contralateral
to the seizure onset area. The changes of the whole
brain WM tracts in MTS still remain unclear. In this
study, we proposed a new method to perform
tract-specific analysis over the whole brain, named
tract-based automatic analysis (TBAA), using a diffusion
spectrum imaging (DSI) template and a tract atlas. We
hypothesized that left and right MTS would affect WM
tract integrity over the whole brain and have different
epileptic networks. In conclusion, we successfully
identified different epileptic networks in left and
right MTS, and found more extensive WM alterations in
right MTS than in left MTS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
