Abstract #4519
Impact of simulated lesions on communicability metrics of the brain structural network
Jennifer Andreotti 1 , Kay Jann 1,2 , Lester Melie-Garcia 1,3 , Stphanie Giezendanner 1 , Thomas Dierks 1 , and Andrea Federspiel 1
1
Department of Psychiatric Neurophysiology,
University Psychiatric Hospital, Bern, BE, Switzerland,
2
Department
of Neurology, University of California Los Angeles, Los
angeles, California, United States,
3
Department
of Neuroinformatics, Cuban Neuroscience Center, Havana,
Havana, Cuba
Communicability is a wider measure of network
connectivity based on the idea that any path between two
nodes will contribute to the total flow of information.
Previous studies suggest that communicability may be
sensitive to reorganizational changes of the brain
network following a lesion. In our study the sensitivity
of communicability related metrics was assessed using
simulated lesions modelled as attacks to nodes and
single edges. Our analysis confirmed that
communicability metrics are an interesting tool to study
the effects of lesions as they are sensitive to changes
in the networks also in regions distant from the main
lesion focus.
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