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Abstract #4520

Evidence of brain damage in neuro asymptomatic HIV positive subjects kept on immune surveillance A DTI study

Namita Singh Saini 1 , Giriraj Singh Gujral 2 , Richa Trivedi 3 , Archana Kumari 3 , Prabhjot Kaur 3 , Pawan Kumar 3 , Subhash Khushu 3 , and Rajender Prasad Tripathi 3

1 NMR, INMAS, Delhi, Delhi, India, 2 Radiodiagnosis, Command Hospital Southern Command, Pune, Maharashtra, India, 3 INMAS, Delhi, India

Neurological damage in HIV infection ranges from Minor Cognitive Motor Dysfunction in the neuroasymptomatic stage to frank HIV associated dementia later, necessitating placement under Highly Active Anti Retroviral Therapy (HAART). Conventional MRI is unable to detect abnormalities in the early stages while Diffusion Tensor Imaging shows reduced Fractional Anisotropy (FA) in Corpus Callosum in later stages. In a cohort of neuroasymptomatic HIV positive individuals we have found evidence of motor progression and reduced FA in Corticospinal Tract even in subjects with CD4 counts above 250, indicating disease progression. Thus DTI instead of CD4 could determine necessity for HAART cover.

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