Abstract #4520
Evidence of brain damage in neuro asymptomatic HIV positive subjects kept on immune surveillance A DTI study
Namita Singh Saini 1 , Giriraj Singh Gujral 2 , Richa Trivedi 3 , Archana Kumari 3 , Prabhjot Kaur 3 , Pawan Kumar 3 , Subhash Khushu 3 , and Rajender Prasad Tripathi 3
1
NMR, INMAS, Delhi, Delhi, India,
2
Radiodiagnosis,
Command Hospital Southern Command, Pune, Maharashtra,
India,
3
INMAS,
Delhi, India
Neurological damage in HIV infection ranges from Minor
Cognitive Motor Dysfunction in the neuroasymptomatic
stage to frank HIV associated dementia later,
necessitating placement under Highly Active Anti
Retroviral Therapy (HAART). Conventional MRI is unable
to detect abnormalities in the early stages while
Diffusion Tensor Imaging shows reduced Fractional
Anisotropy (FA) in Corpus Callosum in later stages. In a
cohort of neuroasymptomatic HIV positive individuals we
have found evidence of motor progression and reduced FA
in Corticospinal Tract even in subjects with CD4 counts
above 250, indicating disease progression. Thus DTI
instead of CD4 could determine necessity for HAART
cover.
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