Independent component analysis with ball-stick model tractography to solve an intra-voxel crossing fiber problem in clinical DTI data

The present study investigates whether independent component analysis with ball-stick model (ICA+BSM) analysis can estimate accurate orientation of multiple fiber bundles in clinical DTI. Simultaion studies assessing the absolute errors for two and three fibers per voxel demonsrated that ICA+BSM provides promising accuracy (median value of error angle = 4.1 and 10.4 for two and three fiber crossing, respectively) even at b-value =1000 s/mm ² and 12 encoding gradients. A preliminary human study suggests these errors may be marginal to isolate three crossing pathways, copus callosum, arcuate fasciculus, and cortico-spinal tracts in the lateral regions of central gyrus/sulcus.

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