Assessing Test-Retest Reliability of Quantitative Tractography Based on Diffusion Spectrum Imaging

Compared with diffusion tensor imaging (DTI) techniques, diffusion spectrum imaging (DSI) has demonstrated its superiority in characterizing complex diffusion patterns related to multiple fiber structures within a single imaging voxel. However, the test-retest reliability of DSI-based tractography remains unclear since assessments so far were generally based on DTI only. Here we present a study to investigate the test-retest reliability of a set of tracts in a group of healthy subjects, with 4 independent DSI scans for each. The outcome tractography measurements, such as fiber counts and tract length, show higher test-retest reliability than previously reported DTI results.

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