Abstract #4533
Aging in White Matter Revealed by Diffusional Kurtosis Imaging
Nan-Jie Gong 1,2 , Chun-Sing Wong 1 , Chun-Chung Chan 3 , Lam-Ming Leung 4 , Yiu-Ching Chu 5 , and Queenie Chan 6
1
Diagnostic Radiology, The University of Hong
Kong, Hong Kong, China,
2
Radiology,
Stanford University, Stanford, CA, United States,
3
Geriatrics
& Medicine, United Christian Hospital, Hong Kong, China,
4
Psychiatry,
United Christian Hospital, Hong Kong, China,
5
Radiology,
Kwong Wah Hospital, Hong Kong, China,
6
Philips
Healthcare, Hong Kong, China
We utilized DKI, and for the first time a
white-matter-model that provided metrics of explicit
neurobiological interpretations in cognitive aging
adults. Whole brain TBSS and regional results suggested
that age-related white matter degenerations were broadly
driven by axonal loss across nearly all tracts. In the
anterior brain which is mostly composed of the late-myelinated
fibre tracts, demyelination was also a major mechanism
contributing to disintegration. Such probable
coexistence of both mechanisms was in line with the
Wallerian degeneration theory and is more supportive of
the anterior-posterior gradient degeneration than the
retrogenesis theory.
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