Abstract #4534
Correlation of DTI measures with neuropsychological scores in HIV-seropositive children
Bhaswati Roy 1 , Rakesh K Gupta 1 , Richa Trivedi 2 , Alok Kumar Singh 3 , Ravindra Kumar Garg 3 , Yogita Rai 4 , Vimla Venkatesh 5 , Mukesh Tripathi 6 , and Chandra M Pandey 7
1
Radiology & Imaging, Fortis Memorial
Research Institute, Gurgaon, Haryana, India,
2
NMR
Reseach Centre, Institute of Nuclear Medicine and Allied
Sciences, Delhi, Delhi, India,
3
Neurology,
King George's Medical University, Lucknow, Uttar
Pradesh, India,
4
Radiodiagnosis,
Sanjay Gandhi Post Graduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, India,
5
Microbiology,
King George's Medical University, Lucknow, Uttar
Pradesh, India,
6
Anaesthesiology, Sanjay
Gandhi Post Graduate Institute of Medical Sciences,
Lucknow, Uttar Pradesh, India,
7
Biostatistics
& Health Informatics, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh,
India
With an aim to assess the integrity of white matter in
HIV positive pediatric patients, DTI and
neuropsychological test battery was performed on 38
HIV-seropositive and 8 HIV-seronegative children born to
HIV-seropositive mothers of same socioeconomic status.
Voxel wise-based technique was implemented for the
analysis of DTI data of participants. We observed
significant changes in FA values in the corpus callosum,
corona radiata, internal capsule. Significant direct
correlation was also observed between FA and cognition
scores relating to memory function. DT MRI could be used
as an early objective marker of HIV related
microstructural brain changes.
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