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Abstract #4535

Differences in diffusional changes of the optic pathways between Multiple Sclerosis and Neuromyelitis Optica using Diffusional Kurtosis Imaging

Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2

1 Department of Radiology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan, 2 Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3 Division of Radiology and Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

The purpose of this study is to evaluate differences in diffusional changes of the optic pathways between multiple sclerosis (MS) and neuromyelitis optica (NMO) using a new method, diffusional kurtosis imaging (DKI) Six NMO, eight MS, and seven healthy volunteers participated in this study. DKI sensitively detected abnormalities in optic tract in NMO patients. According to the past reports, NMO-immunoglobulin G targeting AQP4 is often observed in optic tact. DKI may be a more sensitive biomarker to differentiate between MS and NMO than conventional diffusional evaluations, such as diffusion tensor imaging.

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