Abstract #4538
Correlation of Diffusion Tensor Imaging (DTI) measures with memory dysfunction scores in hypothyroid patients
Subash Khushu 1 , Sadhana Singh 1 , Richa Trivedi 1 , Kavita Singh 1 , Pawan Kumar 1 , and L Ravi Shankar 2
1
NMR Research Centre, INMAS DRDO, Delhi,
delhi, India,
2
Thyroid
Research Centre, INMAS DRDO, Delhi, delhi, India
The aim of our study was to correlate DTI measures (FA
and MD) with memory dysfunction scores in hypothyroid
population. Diffusion tensor tractography (DTT) and PGI-memory
scale (PGIMS) were performed on eight healthy controls
and eight hypothyroid patients. Our results showed the
inverse correlation of memory dysfunction score with FA
of WM tracts (RIFO and LIFO) and positive correlation of
memory dysfunction scores with MD of RATR fibre tract.
These findings suggest that the microstructural changes
in these WM tracts may contribute to underlying
dysfunction in memory in hypothyroidism.
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