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Abstract #4547

MRI quantification of diffusion and perfusion in bone marrow by intravoxel incoherent motion (IVIM) and non-negative least square (NNLS) analysis.

Giulio Gambarota 1 , Antoine Marchand 2 , Eric Hitti 1 , Frederik Monge 1 , Regis Duvauferrier 2 , Raphael Guillin 2 , and Herv Saint-Jalmes 1

1 Universit de Rennes 1, LTSI, Rennes, F-35000, France, 2 Department of Imaging, Rennes University Hospital, Rennes, F-35000, France

The aim of this study was to assess the feasibility of measuring diffusion and perfusion in vertebral bone marrow using the intravoxel incoherent motion (IVIM) approach and to investigate the benefits of the non-negative least square (NNLS) technique for analysis of IVIM data. Results indicated that, for a proper analysis of IVIM data, the use of NNLS is essential especially in cases where the signal-to-noise ratio is low or where motion artifacts and other factors might affect the data quality.

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