MRI quantification of diffusion and perfusion in bone marrow by intravoxel incoherent motion (IVIM) and non-negative least square (NNLS) analysis.
Giulio Gambarota 1 , Antoine Marchand 2 , Eric Hitti 1 , Frederik Monge 1 , Regis Duvauferrier 2 , Raphael Guillin 2 , and Herv Saint-Jalmes 1
Universit de Rennes 1, LTSI, Rennes,
of Imaging, Rennes University Hospital, Rennes, F-35000,
The aim of this study was to assess the feasibility of
measuring diffusion and perfusion in vertebral bone
marrow using the intravoxel incoherent motion (IVIM)
approach and to investigate the benefits of the
non-negative least square (NNLS) technique for analysis
of IVIM data. Results indicated that, for a proper
analysis of IVIM data, the use of NNLS is essential
especially in cases where the signal-to-noise ratio is
low or where motion artifacts and other factors might
affect the data quality.
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