Abstract #4559
Further Evidence for Arterial Spin Labeling Measurement of White Matter Perfusion Using a Multi-Delay Vessel-Encoded Approach
Thomas W Okell 1 , Michael A Chappell 1,2 , Michael E Kelly 1,3 , and Peter Jezzard 1
1
FMRIB Centre, Nuffield Department of
Clinical Neurosciences, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
IBME,
Department of Engineering Sciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
3
Centre
for Core Biotechnology Services, University of
Leicester, Leicester, Leicestershire, United Kingdom
There is some debate regarding the ability of arterial
spin labeling (ASL) to measure perfusion in white matter
(WM). Here a multi-postlabeling delay vessel-encoded ASL
sequence, capable of producing CBF and BAT estimates for
each major brain-feeding artery separately, was used to
demonstrate a significant delay in blood arrival within
a restrictive WM mask compared to that in grey matter,
showing that the WM signal does not arise simply from
partial volume effects. In addition, WM CBF estimates
arise almost entirely from the expected feeding artery,
showing that these measurements are not dominated by
noise.
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