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Abstract #4559

Further Evidence for Arterial Spin Labeling Measurement of White Matter Perfusion Using a Multi-Delay Vessel-Encoded Approach

Thomas W Okell 1 , Michael A Chappell 1,2 , Michael E Kelly 1,3 , and Peter Jezzard 1

1 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 IBME, Department of Engineering Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 Centre for Core Biotechnology Services, University of Leicester, Leicester, Leicestershire, United Kingdom

There is some debate regarding the ability of arterial spin labeling (ASL) to measure perfusion in white matter (WM). Here a multi-postlabeling delay vessel-encoded ASL sequence, capable of producing CBF and BAT estimates for each major brain-feeding artery separately, was used to demonstrate a significant delay in blood arrival within a restrictive WM mask compared to that in grey matter, showing that the WM signal does not arise simply from partial volume effects. In addition, WM CBF estimates arise almost entirely from the expected feeding artery, showing that these measurements are not dominated by noise.

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