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Abstract #4560

Accelerated In Vivo 3D Pseudo-Continuous ASL with Balanced Steady State Free Precession using k-t FOCUSS

Paul Kyu Han 1 , Jong Chul Ye 1 , Seung Hong Choi 2 , and Sung-Hong Park 1

1 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, 2 Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

pCASL is a non-invasive technique that measures blood perfusion. Recently, pCASL with bSSFP has been proposed to overcome the limitations of EPI, however, the low temporal resolution may lead to limited spatial coverage. One potential approach to improve the spatial coverage of pCASL-bSSFP is to use compressed sensing (CS). We implemented the first accelerated in-vivo imaging of 3D pCASL-bSSFP with k-t FOCUSS at 3T for human brain. Experimental results show that CS acceleration by a factor of 4 works well for pCASL-bSSFP, which confirms that combination of CS and pCASL-bSSFP may be a good solution for distortion-free blood perfusion imaging.

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