A Spatially Constrained Temporally Adapted CBF Quantification Method for Arterial Spin Labeling (ASL) Perfusion MRI
Ze Wang 1
Departments of Psychiatry and Radiology,
Perelman School of Medicine, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
Arterial spin labeling (ASL) MRI has a low
signal-to-noise-ratio (SNR). Meanwhile, it has abundant
spatial correlation and temporal prior information that
can be exploited to improve the subsequent cerebral
blood flow (CBF) quantification quality. To use those
priors, we proposed a novel spatially constrained and
temporally adapted method for ASL CBF quantification.
The method demonstrated significantly improved SNR,
spatial image quality, and clinical sensitivity of ASL
CBF using normal healthy subjects data and data from
patients with Alzheimers Disease.
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