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Abstract #4561

A Spatially Constrained Temporally Adapted CBF Quantification Method for Arterial Spin Labeling (ASL) Perfusion MRI

Ze Wang 1

1 Departments of Psychiatry and Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Arterial spin labeling (ASL) MRI has a low signal-to-noise-ratio (SNR). Meanwhile, it has abundant spatial correlation and temporal prior information that can be exploited to improve the subsequent cerebral blood flow (CBF) quantification quality. To use those priors, we proposed a novel spatially constrained and temporally adapted method for ASL CBF quantification. The method demonstrated significantly improved SNR, spatial image quality, and clinical sensitivity of ASL CBF using normal healthy subjects data and data from patients with Alzheimers Disease.

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