In vivo quantification of blood water R 1 change during hypercarbic hyperoxia

The purpose of this study is to quantify the change in blood water R ₁ that results from hypercarbic hyperoxia (i.e., carbogen) administration in humans. Owing to the small-to-negligible effect of hyperoxia on CBF, it is possible to fit for the blood water R ₁ change during carbogen administration by performing sequential experiments with 5%CO ₂ /21%O ₂ /74%N ₂ and 5%CO ₂ /95%O ₂ . Results reveal that blood water R ₁ increases from 0.62 at baseline (21% O ₂ ) to 0.73+/-0.07s ^-1 during carbogen breathing.

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