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Abstract #4579

In vivo quantification of blood water R 1 change during hypercarbic hyperoxia

Lindsey M Dethrage 1 , Carlos C Faraco 1 , Megan K Strother 1 , and Manus J Donahue 1

1 Vanderbilt University, Nashville, Tennessee, United States

The purpose of this study is to quantify the change in blood water R 1 that results from hypercarbic hyperoxia (i.e., carbogen) administration in humans. Owing to the small-to-negligible effect of hyperoxia on CBF, it is possible to fit for the blood water R 1 change during carbogen administration by performing sequential experiments with 5%CO 2 /21%O 2 /74%N 2 and 5%CO 2 /95%O 2 . Results reveal that blood water R 1 increases from 0.62 at baseline (21% O 2 ) to 0.73+/-0.07s -1 during carbogen breathing.

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