Abstract #4580
DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model vs. shutter-speed model. Initial experience.
Guido Hugo Jajamovich 1 , Wei Huang 2 , Cecilia Besa 1 , Xin Li 2 , Aneela Afzal 2 , Hadrien Dyvorne 1 , and Bachir Taouli 1
1
Icahn School of Medicine at Mount Sinai, New
York, NY, United States,
2
Oregon
Health & Science University, Portland, OR, United States
This study quantifies hepatocellular carcinoma (HCC) and
background parenchyma perfusion parameters with DCE-MRI
using two pharmacokinetic models: the Tofts Model (TM)
and the Shutter-Speed Model (SSM). Parameters ve and kep
from the TM and Ktrans and τi from the SSM showed
significant differences between liver parenchyma and HCC,
with better parameter reproducibility in liver
parenchyma compared to HCC for both models and with the
SSM showing worse reproducibility overall. The
differences in τi may possibly reflect differences in
metabolic activity between the two tissues, suggesting
potential utility of this parameter for HCC
characterization.
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