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Abstract #4585

DCE-MRI and PET imaging as a predictive and prognostic biomarker in Osteosarcoma

Junyu Guo 1 , Wilburn E. Reddick 1 , John Glass 1 , Jianrong Wu 1 , M. Beth McCarville 1 , Barry L. Shulkin 1 , Najat C. Daw 1 , and Fariba Navid 1

1 St Jude Children's Research Hospital, Memphis, TN, United States

This study investigated DCE-MRI and 18F-FDG PET for evaluating response to antiangiogenic and neoadjuvant chemotherapy and prognosis of event-free survival (EFS) and overall survival in 42 patients with Osteosarcoma. Ktrans and vp significantly dropped after 24 hours of the first bevacizumab administration. SUVmax strongly correlated with several DCE-MRI parameters at the different time points. Ktrans, tumor volume (TV), and SUVmax at week10 were significantly different between responder and nonresponders. Ktrans at week10 and TV on Day-2 and at week 5 were significantly associated with EFS and overall survival, and could serve as potential prognostic factors for these clinical outcomes.

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