DCE-MRI and PET imaging as a predictive and prognostic biomarker in Osteosarcoma
Junyu Guo 1 , Wilburn E. Reddick 1 , John Glass 1 , Jianrong Wu 1 , M. Beth McCarville 1 , Barry L. Shulkin 1 , Najat C. Daw 1 , and Fariba Navid 1
St Jude Children's Research Hospital,
Memphis, TN, United States
This study investigated DCE-MRI and 18F-FDG PET for
evaluating response to antiangiogenic and neoadjuvant
chemotherapy and prognosis of event-free survival (EFS)
and overall survival in 42 patients with Osteosarcoma.
Ktrans and vp significantly dropped after 24 hours of
the first bevacizumab administration. SUVmax strongly
correlated with several DCE-MRI parameters at the
different time points. Ktrans, tumor volume (TV), and
SUVmax at week10 were significantly different between
responder and nonresponders. Ktrans at week10 and TV on
Day-2 and at week 5 were significantly associated with
EFS and overall survival, and could serve as potential
prognostic factors for these clinical outcomes.
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