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Abstract #4586

Estimation of R1 changes from Dual bolus DCE-MRI in Vestibular Schwannomas and Meningiomas of Patients Undergoing Treatment of Bevacizumab

Xiaoping Zhu 1 , Sha Zhao 2 , Ka-Loh Li 1 , and Alan Jackson 1

1 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom, 2 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom

In dual-bolus-DCE-MRI, R1 values prior to the main-dose (R1init) were estimated in NF2 patients. R1init are significantly larger than native R1 (R1N) in vascular schwannomas and meningiomas, but not in normal brain tissue. R1init estimated from prebolus kinetic analysis showed close to those derived from variable flip angle (VFA)-GRE sequences. The R1N and R1init maps from VFA were then used in kinetic analysis of prebolus and main-dose DCE data respectively. The Ktrans from prebolus (one-fifth dose) were comparable to those from high spatial resolution main-dose data, achieving the same detection of changes in the brain tumors induced by VEGF-blockade.

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