Abstract #4589
Effects of Chronic Ocular Hypertension and Hypotensive Drug Treatment on Ocular Physiology and Biotransport using Dynamic Gadolinium-enhanced MRI
Leon C. Ho 1,2 , Ian P. Conner 3 , Seong-Gi Kim 1,4 , Ed X. Wu 2 , Chi-Wai Do 5 , Gadi Wollstein 3 , Joel S. Schuman 3 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, Department of
Radiology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
4
Center
for Neuroscience Imaging Research, Institute for Basic
Science (IBS), Dept. of Biological Sci, SKKU, Suwon,
Korea,
5
School of Optometry, The Hong Kong
Polytechnic University, Hung Hom, Hong Kong, China
Balanced aqueous humor flow dynamics is crucial to
maintain healthy ocular physiology. Imbalanced aqueous
humor flow dynamics would lead to altered intraocular
pressure and retinal damage or visual loss in glaucoma
disease. To date, the relationships between eye
pressure, aqueous humor flow and glaucoma are not fully
evaluated. Gd-enhanced MRI may non-invasively visualize
flow dynamics of aqueous humor. In this study, dynamic
Gd-enhanced MRI was employed to evaluate in vivo the
ocular physiology and biotransport in a rat model of
microbead-induced ocular hypertension and in healthy,
normotensive rats after topical applications of 3
different ophthalmic hypotensive eye drops.
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