Abstract #4590
Re-use of subject-specific AIFs are warranted in longitudinal DCE-MRI
Christopher Larsson 1,2 , Jayashree Kalpathy-Cramer 3 , Atle Bjrnerud 1,4 , Patrick Y. Wen 5 , Tracy T. Batchelor 6,7 , Rakesh K. Jain 6 , A. Gregory Sorensen 3,8 , and Kyrre E. Emblem 1,3
1
The Intervention Centre, Oslo University
Hospital, Rikshospitalet, Oslo, Oslo, Norway,
2
Faculty
of Medicine, University of Oslo, Oslo, Oslo, Norway,
3
Department
of Radiology and Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General Hospital and
Harvard Medical School, Boston, Massachusetts, United
States,
4
Department
of Physics, University of Oslo, Oslo, Norway,
5
Center
for Neuro-Oncology, Dana-Farber/Brigham and Womens
Cancer Center and Harvard Medical School, Massachusetts,
United States,
6
Department
of Radiation Oncology, Massachusetts General Hospital
and Harvard Medical School, Boston, Massachusetts,
United States,
7
Department
of Neurology, Massachusetts General Hospital and Harvard
Medical School, Boston, Massachusetts, United States,
8
Siemens
Healthcare, Malvern, PA, United States
The role of DCE-MRI for assessment of tumor permeability
in clinical decision making remains controversial. The
usefulness of this technique is limited by the low
reproducibility of parameters such as the capillary
permeability transfer constant Ktrans in longitudinal
analysis. In this study we demonstrate substantial
improvements in reproducibility of Ktrans by re-use of
patient-specific arterial input functions (AIFs)
compared to determining the AIF at each scan. This
suggests that patient-specific AIFs adjust for
variations in systemic circulation while minimizing
scan-rescan variability.
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