Abstract #4591
Comparison of Manually Selected Arterial Input Function and Standard Radiological Arterial Input Function in MR Estimation of Permeability Parameters Using Model Selection Approach
Siamak P. Nejad-Davarani 1,2 , Hassan Bagher-Ebadian 3,4 , Wilson B. Chwang 3 , James R. Ewing 1,4 , Ashley VanSlooten 5 , Lonni Schultz 5 , Ali S. Arbab 3 , and Rajan Jain 6
1
Department of Neurology, Henry Ford
Hospital, Detroit, MI, United States,
2
Department
of Biomedical Engineering, University of Michigan, Ann
Arbor, MI, United States,
3
Department
of Radiology, Henry Ford Hospital, Detroit, MI, United
States,
4
Department
of Physics, Oakland University, Rochester, MI, United
States,
5
Department
of Biostatistics, Henry Ford Hospital, Detroit, MI,
United States,
6
Department
of Radiology, NYU Langone Medical Center, New York, NY,
United States
We have compared the results of using a Standard
Radiological Arterial Input Function (SRAIF) vs. the
Manually Selected Arterial Input Function (MSAIF) for
estimation of permeability parameters in Dynamic
Contrast Enhanced (DCE)-MR images of rats using a nested
model selection approach. DCE experiments were performed
using Gd-DTPA and Gadofosveset contrast agents which
have different molecular sizes. The results show that
when estimation in done using the two AIFs, there is
less variation in the estimated value of the forward
vascular transfer constant (Ktrans) compared to the
estimated values of the extracellular-extravascular
space volume (ve) and plasma volume (vp).
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