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Abstract #4592

Bias and precision of three different DCE-MRI analysis software packages: a comparison using simulated data

Greg O Cron 1,2 , Steven Sourbron 3 , Daniel P Barboriak 4 , Rhys Abdeen 2 , Matthew Hogan 2,5 , and Thanh B Nguyen 1,2

1 Medical Imaging, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, 2 University of Ottawa, Ottawa, Ontario, Canada, 3 Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds, United Kingdom, 4 Radiology, Duke University Medical Center, Durham, North Carolina, United States, 5 Neuroscience, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Software packages (SPs) for analysis of DCE-MRI data abound. However, it is unclear how consistent they are with each other, which impedes standardization. The purpose of this work was to compare three DCE-MRI SPs, using identical simulated data, to see if the SPs have different bias and precision. We observed differences between the SPs, especially in terms of how they react to noise. These results support the notion that the bias and precision of a DCE-MRI analysis may be affected by the particular SP used. In conclusion, only a single SP should be used for a given DCE-MRI study.

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