Abstract #4600
Tau b : A Metabolic Neuroimaging Biomarker
William D. Rooney 1 , Xin Li 1 , John W. Grinstead 2 , Edward A. Neuwelt 3 , and Charles S. Springer, Jr. 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Siemens
Healthcare, Portland, Oregon, United States,
3
Blood-Brain-Barrier
Program, Oregon Health & Science University, Portland,
Oregon, United States
Monomeric Gd(III) chelate contrast agents (CA) do not
extravasate in normal brain. In that case, shutter-speed
pharmacokinetic analysis of DCE-MRI data allows mapping
of the mean capillary water lifetime, tau
b
.
The magnitude of this biomarker is inversely
proportional to neuronal Na
+
/K
+
ATPase
[NKA] activity. However, in glioblastoma multiforme
brain tumors these CAs extravasate rapidly. Here, we use
an intravascular SPIO CA, Ferumoxytol, which does not
extravasate during the study. It reveals that tumor tau
b
is
dramatically elevated: NKA activity is drastically
reduced.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
