Abstract #4601
Dual Compartmental Fitting of Dynamic Susceptibility Contrast MRI in Early Ischemic Stroke
M. Ethan MacDonald 1,2 , Estee Lee 1,2 , Ting Lee 2,3 , Jordan Woehr 4 , Chris d'Esterre 2,5 , Michael R Smith 4,5 , and Richard Frayne 2,5
1
Biomedical Engineering, University of
Calgary, Calgary, AB, Canada,
2
Seaman
Family Magnetic Resonance Research Centre, Hotchkiss
Brain Institute, Foothills Medical Centre, Calgary, AB,
Canada,
3
Imaging
Research Labs, Robarts Research Institute, London, ON,
Canada,
4
Electrical
& Computer Engineering, University of Calgary, Calgary,
AB, Canada,
5
Radiology
& Clinical Neurosciences, University of Calgary,
Calgary, AB, Canada
In this work we use dynamic susceptibility contrast MR
imaging and fit a duel compartmental model to the
residue function. The proposed duel compartmental model
has been used in CT perfusion with great success,
consisting of a rectangular function and exponential
decay. The model is interactively fit to the residue
function with an iterative least squares conjugate
gradient algorithm. Parametric maps and goodness of fit
maps were produced for an acute ischemic stroke patient.
Fit quality is high in regions of normal flow, but where
flow is low, <10 ml/100 g/min, the quality of the fit is
diminished.
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