R2*
curve difficult. However, through a numeric simulation
where cells and vessels were randomly distributed while
EES fraction and vascular permeability controlled, a
linear relationship between EES fraction and ratio of
the two parameters K1 and K2 in Weisskoff model has been
demonstrated, which on the other hand varied little with
vascular permeability. As a consequence, a potential
approach to measure relative Ve by DSC-MRI is feasible
and clinical data is expected to prove the theory.
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