Abstract #4605
Neuroprotective effects of erythropoietin on white matter development in preterm infants investigated with tract based spatial statistics
Ruth L O'Gorman 1 , Petra S Huppi 2 , Hans Ulrich Bucher 3 , Brigitte M Koller 3 , and Cornelia F Hagmann 3
1
University Children's Hospital, Zurich,
Switzerland,
2
Division
of Child Growth & Development, University of Geneva,
Geneva, Switzerland,
3
Department
of Neonatology, University Hospital of Zurich, Zurich,
Switzerland
Erythropoietin (Epo) is a haematopoetic cytokine which
has been shown to have neuroprotective and
neuroregenerative effects on the brain. This study
investigates the effects on Epo on the development of
white matter in preterm infants. Tract based spatial
statistics (tbss) analysis of diffusion tensor imaging
data from 58 preterm infants revealed increased FA in
Epo-treated infants in the corpus callosum, internal and
external capsule, corona radiata, centrum semiovale, and
the corticospinal tract. Neurodevelopmental follow-up
data should help to clarify the developmental
significance of these findings, but early Epo
administration appears to improve white matter
development in preterm infants.
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