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Abstract #4606

The Effect of Maternal Substance Abuse on Fetal Brain Growth

Devasuda Anblagan 1,2 , Kaiming Yin 1 , Rebecca M Reynolds 3 , Fiona Denison 2 , Mark E Bastin 4 , Colin Studholme 5 , James P Boardman 2 , Scott I Semple 1,3 , Neil Roberts 1 , and Jane E Norman 2

1 Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, 2 MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom, 3 Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom, 4 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 5 Department of Pediatrics, University of Washington, Seattle, Washington, United States

Retrospective motion correction is now possible for fetal brain MRI at 2nd and 3rd trimester, making it possible to quantify brain development in utero. The Isotropic Cavalieri method has been applied to analyse 3D reconstructed fetal brain images from 3638 weeks to measure brain growth in fetuses exposed to maternal substance abuse compared with non-exposed fetuses. Fetal intracranial and cerebral volumes were reduced by maternal substance abuse, and cerebellum volume and pial surface area in female exposed fetuses are significantly smaller compared with male exposed fetuses. Analyses will be extended to include fetal brain measurement at 2427 weeks.

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