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Abstract #4607

Impaired white matter development in extremely low birth weight infants with previous brain hemorrhage

Xiawei Ou 1 , Raghu Ramakrishnaiah 1 , Charles Glasier 1 , Sarah Mulkey 1 , Zhaohua Ding 2 , and Jeffrey Kaiser 3

1 Unversity of Arkansas for Medical Sciences, Little Rock, AR, United States, 2 Vanderbilt University, TN, United States, 3 Baylor College of Medicine, TX, United States

The purpose of this study is to evaluate white matter in extremely low birth weight (ELBW) infants with or without previous hemorrhage in the brain. We enrolled ELBW infants for MRI examination at term-equivalent age and reviewed their medical records of IVH diagnosis by routine ultrasound, divided them to different groups according to the extent of hemorrhage, and compared their white matter respectively to healthy newborn term infants by conventional MRI and DTI. Our results suggested that previous hemorrhage in the brain has significant effects on white matter development in ELBW infants at term-equivalent age, and that ELBW infants with no brain hemorrhage are more likely to have normal white matter development.

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