Abstract #4609
Sensitivity of magnetic susceptibility to white matter health in Cerebral Palsy
Zoe A Englander 1,2 , Wei Li 2 , Anastasiya Batrachenko 2 , Jessica Sun 3,4 , Mohamad Mikati 3,4 , Joanne Kurtzberg 3,4 , Chunlei Liu 2,5 , and Allen W Song 2,5
1
Biomedical Engineering, Duke University,
Durham, NC, United States,
2
Brain
Imaging and Analysis Center, Duke University, Durham,
North Carolina, United States,
3
Pediatrics,
Duke University, Durham, North Carolina, United States,
4
The
Robertson Cell and Translational Therapy Center, Duke
University, Durham, North Carolina, United States,
5
Radiology,
Duke University, Durham, North Carolina, United States
We investigate the use of quantitative susceptibility
mapping (QSM) to detect myelin specific white matter
(WM) damage in Cerebral Palsy (CP). The theoretical
dependence of magnetic susceptibility on white matter
fiber angle due to the presence of myelin is well
characterized. QSM anisotropy was compared between
healthy and damaged white matter in CP. By localizing
voxels with aberrant anisotropy characteristics,
specific regions of WM damage were identified.
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