Abstract #4611
ABNORMALITIES OF THE BRAIN FUNCTIONAL CONNECTOME IN PEDIATRIC PATIENTS WITH MULTIPLE SCLEROSIS
Maria A. Rocca 1,2 , Paola Valsasina 1 , Sara Sala 1 , Vittorio Martinelli 3 , Angelo Ghezzi 4 , Pierangelo Veggiotti 5 , Andrea Falini 6 , Giancarlo Comi 3 , and Massimo Filippi 1,3
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, Mi, Italy,
3
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy,
4
UO
Neurologia 2 - Centro Studi Sclerosi Multipla, Ospedale
di Gallarate, Gallarate, VA, Italy,
5
Child
Neuropsychiatry Unit, National Neurologic Institute "C.
Mondino", Pavia, PV, Italy,
6
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Resting state functional MRI (RS fMRI) and graph theory
were applied to investigate the functional organization
of large-scale brain networks (connectome) in 52
pediatric patients with multiple sclerosis (MS) and 16
healthy controls (HC). Pediatric MS patients compared
with HC showed a relatively preserved global topology of
functional network organization. The local
reorganization of functional network in pediatric MS
patients involved only a few infratentorial and
supratentorial brain regions including the cerebellum,
basal ganglia and paritetal/occipital areas. The limited
reorganization of brain topology found in pediatric MS
patients might contribute to explain their better
clinical outcome.
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