Abstract #4613
Pulsed arterial spin labeling in 2-year-old children with congenital diaphragmatic hernia repair and occlusion of the right common carotid artery after neonatal ECMO therapy: Quantitative cerebral perfusion imaging at 3.0 T
Claudia Hagelstein 1 , Frank G. Zoellner 2 , Meike Weidner 1 , Thomas Schaible 3 , Fabian Zimmer 2 , Lothar R. Schad 2 , Stefan O. Schoenberg 1 , Katrin Zahn 4 , and K. Wolfgang Neff 1
1
Institute of Clinical Radiology and Nuclear
Medicine, University Medical Center Mannheim, Heidelberg
University, Mannheim, Baden-Wrttemberg, Germany,
2
Computer
Assisted Clinical Medicine, Heidelberg University,
Mannheim, Baden-Wrttemberg, Germany,
3
Dept.
of Pediatrics, University Medical Center Mannheim,
Heidelberg University, Mannheim, Baden-Wrttemberg,
Germany,
4
Dept.
of Pediatric Surgery, University Medical Center
Mannheim, Heidelberg University, Mannheim,
Baden-Wrttemberg, Germany
Purpose: To quantify cerebral perfusion in children
after congenital diaphragmatic hernia repair with right
common carotid artery (rCCA) occlusion after ECMO
therapy using pASL. Materials and Methods: In 14
patients the rCCA was occluded after ECMO therapy
(primary ligation or secondary occlusion after
reconstruction). 15 patients without ECMO served as
controls. Results: In patients with rCCA occlusion
subcortical perfusion of the right hemisphere was
significantly lower compared to the left hemisphere
(p=0.011). In one third of the patients with rCCA
occlusion, relCBF of the right hemisphere was reduced of
more than 20%. Conclusion: Based on the possible
hypoperfusion of the right hemisphere after rCCA
occlusion, reconstruction of the rCCA should be
preferred after ECMO therapy.
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