Abstract #4614
Regional Microstructure And Volume Abnormalities In The Corpus Callosum Of Neonates With Transposition Of The Great Artery Undergoing Cardiopulmonary By Pass Surgery.
Malek Makki 1 , Jitka Majerova 2 , Walter Knirsch 3 , Beatrice Latal 4 , and Cornelia Hagmann 2
1
MRI Research, Univesity Children Hospital of
Zurich, Zurich, Switzerland,
2
Neonatalogy,
University Hospital of Zurich, Switzerland,
3
Cardiology,
University Children Hospital of Zurich, Switzerland,
4
Child
Development Center, University Children Hospital of
Zurich, Switzerland
DTI and 3D volumetric acquisitions were preformed on 15
neonates with transposition of the great artery before
and after surgery and compared to 20 age matched healthy
controls. We subdivided the corpus callosum into 5
parts: genu, rostrum, body, isthmus, and splenium and
compared their volume and their DTI indices. Pre and
post surgical patients had significantly lower
sub-structural volumes compare to healthy controls but
no correlation with DTI indices. Altered DTI indices
were observed in all sub-structures in the post surgical
group while pre-surgical patients showed altered DTI
indices in the splenium and rostrum.
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