Abstract #4621
REGIONAL HIPPOCAMPAL INVOLVEMENT IN PAEDIATRIC MULTIPLE SCLEROSIS: A RADIAL MAPPING MR STUDY
Maria Elisa Morelli 1 , Maria A. Rocca 1 , Elisabetta Pagani 1 , Lucia Moiola 2 , Angelo Ghezzi 3 , Andrea Falini 4 , Giancarlo Comi 2 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
3
UO
Neurologia 2 - Centro Studi Sclerosi Multipla, Ospedale
di Gallarate, Gallarate, VA, Italy,
4
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Manual hippocampal tracing of 3DT1-weighted contiguous
coronal slices and radial mapping analysis were applied
to assess the patterns of global and regional
hippocampal volume changes in paediatric multiple
sclerosis (MS) patients. Global hippocampal volume was
reduced, bilaterally, in patients versus HC. In
patients, radial atrophy affected the cornu Ammonis,
subiculum and dentate gyrus (DG) of both hippocampi,
mostly on the right side. Compared to cognitively
preserved patients, those with cognitive impairment had
radial atrophy of the subiculum and DG of the right
hippocampus. MR-based radial mapping analysis is
feasible for developing reliable markers of disease
progression in MS.
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