Alterations in Cardiac-Correlated Brain BOLD Signal in Children with Chronic Kidney Disease
Hua-Shan Liu 1 , Abbas F. Jawad 2 , Nina Laney 2 , Stephen Hooper 3 , Jerilynn Radcliffe 2 , Divya Moodalbail 2 , Christos Davatzikos 1 , Robert Schultz 2 , Susan Furth 2 , and John Detre 1
University of Pennsylvania, Philadelphia,
PA, United States,
Childrens Hospital of Philadelphia, Philadelphia, PA,
of North Carolina School of Medicine, Chapel Hill, NC,
We investigated the group difference of the
cardiovascular fluctuation-induced modulation in BOLD
fMRI signal between patients with chronic kidney disease
(CKD) and control subjects. We found that CKD patients
showed a significantly increased cardiac modulation in
BOLD fMRI in the anterior cingulated cortex as compared
with control subjects.
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