Abstract #4625
Gender Specific Effects on the Development of White Matter Tracts after Preterm Birth
Devasuda Anblagan 1,2 , Mark E Bastin 3 , Sarah Sparrow 2 , Chinthika Piyasena 4 , Rozi Pataky 5 , Emma Moore 2 , Graham Wilkinson 5 , Neil Roberts 1 , Scott I Semple 1,4 , and James P Boardman 2
1
Clinical Research Imaging Centre, University
of Edinburgh, Edinburgh, United Kingdom,
2
MRC
Centre for Reproductive Health, University of Edinburgh,
Edinburgh, United Kingdom,
3
Centre
for Clinical Brain Sciences, University of Edinburgh,
Edinburgh, United Kingdom,
4
Centre
for Cardiovascular Sciences, University of Edinburgh,
Edinburgh, United Kingdom,
5
NHS
Lothian, Edinburgh, United Kingdom
Preterm delivery affects 11% of all live births and is a
leading cause of neurodevelopmental impairment and
suboptimal educational achievement in childhood. Some of
the adverse neurodevelopmental sequelae of preterm birth
are gender-specific and may be neuroprotective
strategies: preterm males have a worse
neurodevelopmental outcome than females. We present the
first application of an automatic single seed point
tractography-based segmentation method, probabilistic
neighborhood tractography, to study the gender specific
effect on developing white matter tracts in preterm
infants. Our work demonstrates increased diffusivities
and reduced fractional anistropy in the cingulum
cingulate gyri of female preterm infants compared with
male equivalents.
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