Abstract #4626
ASL perfusion MRI in hypothermia treated infants with hypoxic ischemic encephalopathy
Arzu Kovanlikaya 1 , Linda Heier 1 , Jonathan P Dyke 2 , Jeffrey M Perlman 3 , and Allison Dunning 4
1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
2
Citigroup
Biomedical Imaging Center, Weill Cornell Medical
College, New York, NY, United States,
3
Pediatrics,
Weill Cornell Medical College, New York, NY, United
States,
4
Public
Health/Biostatistics, Weill Cornell Medical College, New
York, NY, United States
Cerebral perfusion in subjects with HIE after
hypothermia have not been well described. The purpose of
this study was to assess perfusion on ASL and compare to
conventional MRI in the second week of life. CBF values
were compared to normals reported in the literature.
Subjects with qualitative basal ganglia injury on
conventional MR had lower CBF. Relative hyperemia in
deep gray matter with no corresponding qualitative
abnormality may be related to timing of injury
evolution. CBF can quantified by ASL in hypothermia
treated infants in the second week of life. Longitudinal
studies are needed to evaluate the progression of
hyperperfusion.
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