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Abstract #4626

ASL perfusion MRI in hypothermia treated infants with hypoxic ischemic encephalopathy

Arzu Kovanlikaya 1 , Linda Heier 1 , Jonathan P Dyke 2 , Jeffrey M Perlman 3 , and Allison Dunning 4

1 Radiology, Weill Cornell Medical College, New York, NY, United States, 2 Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY, United States, 3 Pediatrics, Weill Cornell Medical College, New York, NY, United States, 4 Public Health/Biostatistics, Weill Cornell Medical College, New York, NY, United States

Cerebral perfusion in subjects with HIE after hypothermia have not been well described. The purpose of this study was to assess perfusion on ASL and compare to conventional MRI in the second week of life. CBF values were compared to normals reported in the literature. Subjects with qualitative basal ganglia injury on conventional MR had lower CBF. Relative hyperemia in deep gray matter with no corresponding qualitative abnormality may be related to timing of injury evolution. CBF can quantified by ASL in hypothermia treated infants in the second week of life. Longitudinal studies are needed to evaluate the progression of hyperperfusion.

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