Meeting Banner
Abstract #4629

Visualization of Intra-Thalamic Anatomy with White-Matter-nulled MPRAGE at 7T

Thomas Tourdias 1,2 , Manojkumar Saranathan 2 , Ives R Levesque 2 , Jason Su 2 , and Brian K Rutt 2

1 Service de NeuroImagerie Diagnostique et Thrapeutique, CHU Pellegrin - Universit de Bordeaux, Bordeaux, France, 2 Department of Radiology, Stanford University, Stanford, California, United States

We present a 3D-MPRAGE pulse sequence at 7T specifically optimized to visualize the thalamic anatomy. Simulations of the MPRAGE signal behavior using our intra-thalamic T1 measurements and empirical optimization in volunteers showed that (i) nulling the signal of the white matter (WM), (ii) increasing the time between two inversion pulses, (iii) increasing the length of the readout, and (iv) using a low flip angle provided the best tradeoff between thalamic signal, intra-thalamic contrast while limiting the blur. This method allowed to accurately and reproducibly delineate 15 thalamic nuclei in healthy controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here