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Abstract #4628

Hippocampal Shape Analysis in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: The Effect of Cranial Radiotherapy

Qing Ji 1 , John O. Glass 1 , Michelle N. Edelmann 2 , Kevin R. Krull 2 , Robert J. Ogg 1 , and Wilburn E. Reddick 1

1 Radiological Science, St.Jude Children's Research Hospital, Memphis, TN, United States, 2 Epidemiology & Cancer Control, St.Jude Children's Research Hospital, Memphis, TN, United States

Hippocampal volume and shape were examined in two groups of adult survivors of childhood ALL and compared to healthy controls using the SPHARM statistical shape model. Survivors were treated with either only chemotherapy or cranial radiotherapy (CRT) and chemotherapy. The mean hippocampal volumes of both survivor groups were lower than that of healthy controls, but did not reach statistical significance. Abnormal shape deformations were found primarily in the right hippocampus of survivors treated with CRT. Since the shape abnormality may correlate with hippocampal damage, the results of this study suggest that radiation may cause more damage to the hippocampi than chemotherapy alone in adult survivors of childhood ALL.

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