Abstract #4634
Quantification of the Cerebellar Lobe Volumes using a 2D T2 TSE PROPELLER Sequence: Reliability Analysis.
Marco Piccirelli 1 , Alexander A. Tarnutzer 2 , Werner Wichmann 1 , Antonios Valavanis 1 , Dominik Straumann 2 , and Franziska C.S. Altorfer 1
1
Neuroradiology, University Hospital Zurich,
Zurich, ZH, Switzerland,
2
Neurology,
University Hospital Zurich, Zurich, ZH, Switzerland
Cerebellar volumetry correlates multiple clinical
findings (ataxia, seizures, psychiatric symptoms) with
localized cerebellar atrophy. Therefore, researchers
quantified the volume of cerebellar parts using
high-resolution 3D-T1-SPGR sequences, which has an
intrinsic low CSF/GM contrast and is motion-sensitive.
Nevertheless, the coarse volumetry reported in clinical
studies is corrupted by the low resolution of clinical
3D-T1-SPGR. To avoid artifacts, we propose an
intrinsically motion insensitive PROPELLER 2D-T2-TSE to
clearly depict cerebellar borders and quantify
cerebellar lobe volumes. These results set the basics
for a clinically useable quantification of cerebellar
atrophy and give a reference to further volumetric
analysis of individual cerebellar lobes.
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