Abstract #4635
High Resolution Imaging of the deep cerebellar nuclei at 7Tesla
Mike Bruegger 1,2 , Michael Wyss 1 , Bernd Daeubler 3 , Daniel Nanz 4 , Alex Ringenbach 5 , David Brunner 1 , and Klaas Pruessmann 1
1
Institute for Biomedical Engineering,
University of Zurich and ETH, Zurich, Zurich,
Switzerland,
2
Center
of Dental Medicine, University of Zurich, Zurich,
Zurich, Switzerland,
3
Department
of Neuroradiology, University Hospital Zurich, Zurich,
Switzerland,
4
Department
of Radiology, University Hospital Zurich, Zurich,
Switzerland,
5
Institute
for Medical and Analytical Technologies, University of
Applied Sciences of Northwestern Switzerland, Muttenz,
Basel, Switzerland
The deep cerebellar nuclei (dentate, fastigial, globose,
emboliforme) are of significant functional importance,
but difficult to investigate in detail non-invasively
because of their small size and tight arrangement. This
work presents a modified 3D-MPRAGE sequence with high
spatial resolution (voxel size=0.275mm3) in the gray
matter nulling regime at 7T. Focusing on the dentate
nuclei (DN) bilaterally, we aimed to contribute to the
ongoing debate linking handedness, size and hemispheric
asymmetry by examining 26 healthy volunteers (13
right/left handed). We revealed a significantly smaller
left DN irrespective of handedness, age and sex.
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