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Abstract #4647

Developmental trajectories of cerebrovascular reactivity in healthy children

Jackie Leung 1 and Andrea Kassner 1,2

1 Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Non-invasive imaging strategies can assess cerebrovascular reactivity (CVR) by quantifying blood flow changes in response to a vasoactive stimulus. This measure has become a valuable tool in the clinical assessment of cerebrovascular disease. However, little is currently known about CVR from childhood through adolescence. The purpose of this study was to use BOLD MRI to determine how CVR changes with age in healthy children. We observed that CVR increases linearly with age up to the late teens, when a sudden decrease is observed. In contrast cerebral blood flow steadily decreased throughout the measured age range.

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