Abstract #4647
Developmental trajectories of cerebrovascular reactivity in healthy children
Jackie Leung 1 and Andrea Kassner 1,2
1
Physiology and Experimental Medicine, The
Hospital for Sick Children, Toronto, Ontario, Canada,
2
Medical
Imaging, University of Toronto, Toronto, Ontario, Canada
Non-invasive imaging strategies can assess
cerebrovascular reactivity (CVR) by quantifying blood
flow changes in response to a vasoactive stimulus. This
measure has become a valuable tool in the clinical
assessment of cerebrovascular disease. However, little
is currently known about CVR from childhood through
adolescence. The purpose of this study was to use BOLD
MRI to determine how CVR changes with age in healthy
children. We observed that CVR increases linearly with
age up to the late teens, when a sudden decrease is
observed. In contrast cerebral blood flow steadily
decreased throughout the measured age range.
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