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Abstract #4653

Hemispherical asymmetry contributes to preserved language abilities in alcohol dependents: A combined 1H MRS and VBM approach

Deepika Bagga 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , Mohan lal Garg 2 , Debajyoti Bhattacharya 3 , Subash Khushu 1 , and Namita Singh 1

1 NMR Research centre, INMAS, Delhi, delhi, India, 2 Department of Biophysics, Panjab University, Chandigarh, Punjab, India, 3 Department of psychiatry, Base Hospital, Delhi, delhi, India

Language abilities are primarily left lateralized and relatively preserved in alcohol dependents. A recent fMRI study at our centre has also suggested a probable involvement of left parieto-temporal network in maintaining language functions. Thus, to assess the metabolic and structural basis of preserved language abilities, proton in vivo MRS study on parietal and temporal lobe bilaterally and whole brain VBM study were performed on alcohol dependent subjects and healthy controls. The preserved metabolite ratios and intact gray and white matter volumes in left hemisphere as compared to right hemisphere might contribute to preserved language abilities in alcohol dependent subjects.

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