Abstract #4654
Effects of Propofol Anesthesia and Sex on Cerebral Blood Flow
Pelin Aksit Ciris 1 , Maolin Qiu 2 , and R. Todd Constable 3
1
Radiology, Brigham and Women's Hospital,
Harvard Medical School, Boston, MA, United States,
2
Diagnostic
Radiology, Yale University, School of Medicine, New
Haven, CT, United States,
3
Diagnostic
Radiology, Neurosurgery, and Biomedical Engineering,
Yale University, School of Medicine, New Haven, CT,
United States
We present whole brain quantification of Cerebral Blood
Flow at rest and during Propofol administration across a
cohort of 32 normal male and female subjects, and the
highlight significant differential effects of sex and
anesthesia. Our findings were in good agreement with the
limited available literature. Such variations should be
considered in the interpretation of perfusion or fMRI
studies conducted under anesthesia. Improved
understanding of the mechanisms underlying these
differences, could lead to more specific models of
cerebrovascular responses, improved assessment of
anesthetic requirements and better management of
anesthesia in all patients.
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