Cerebral blood flow, vascular reactivity and oxygen consumption in healthy aging.
J. B. De Vis 1 , E. T. Petersen 1 , A. Bhogal 1 , L. J. Kappelle 2 , and J. Hendrikse 1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Utrecht,
Previous studies have found conflicting results when it
comes to age-related changes in brain hemodynamic
parameters. The purpose of this study was to investigate
the influence of age on brain hemodynamics. For this
purpose, calibrated MRI was performed in a group of
young healthy subjects and a group of elderly healthy
subjects. We found lower whole brain and regional
cerebral blood flow, oxygen extraction fraction and
oxygen consumption in the elderly subjects compared to
the young subjects.
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