Differentiating neural and vascular effects of caffeine in resting state connectivity study

Caffeine is known to modify both the levels of cerebral persuion and alertness, affecting the resting state connectivity results. Existing studies have demonstrated that the induced connectivity changes are mainly the result of neural stimluation, the role and ratio effect of the perfusion part is yet to be explored. We use flow dephasing dark blood method the aquire resting state data and compare them between normal BOLD data under the pre- and post-caffeine intake conditions. We found that reduction in perfusion during caffeine intake may actually account for a greater effect than expected, and is opposite to caffeine's neural enhancement effects.

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