Abstract #4659
Metabolic aberrations underlying impaired abstract reasoning abilities in chronic alcoholism: A proton magnetic resonance spectroscopy imaging study
Deepika Bagga 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , Mohan lal Garg 2 , Debajyoti Bhattacharya 3 , Subash Khushu 1 , and Namita Singh 1
1
NMR Research centre, INMAS, Delhi, delhi,
India,
2
Department
of Biophysics, Panjab University, Chandigarh, Punjab,
India,
3
Department
of psychiatry, Base Hospital, Delhi, delhi, India
Proton in vivo Magnetic Resonance Spectroscopy (MRS)
study on frontal and parietal brain regions was
performed on alcohol dependents and healthy controls to
look for the metabolic aberrations underlying the
abstract reasoning deficits observed in alcohol
dependents as shown by a recent fMRI study at our
centre. This study suggested the probable role of fronto-parietal
circuit for poorer abstract reasoning abilities. A
significant reduction in NAA/Cr and Glx/Cr ratios and a
significant increase in Cho/Cr and Ins/Cr ratios was
observed which could possibly account for impaired
abstract reasoning abilities in alcohol dependents.
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