Abstract #4675
Increased grey matter transit times are associated with white matter hyper intensities
Jan Willem van Dalen 1 , Henri J M M Mutsaerts 2 , Lisa S M Eurelings 1 , Martijn D Steenwijk 3 , Hugo Vrenken 3 , Matthan W A Caan 2 , Aart J Nederveen 2 , and Edo Richard 1
1
Neurology, Academic Medical Center,
Amsterdam, Noord Holland, Netherlands,
2
Radiology,
Academic Medical Center, Amsterdam, Noord Holland,
Netherlands,
3
Radiology
and Nuclear Medicine, VU University Medical Center,
Noord Holland, Netherlands
White matter hyper intensities of presumed vascular
origin (WMH) are a common finding on brain MRI in the
elderly, associated with hypertension, cognitive decline
and mortality. Although they are thought to arise from
low grade ischemia, the relation between WMH load and
cerebral blood flow (CBF) remains to be fully
elucidated. In this study, WMH and CBF data, including
transit time, were obtained from 3D FLAIR and pCASL
(including vascular crushing) MRI scans of 196 community
dwelling elderly with systolic hypertension. Unlike
total and crushed CBF, grey matter transit time was
significantly associated with increasing WMH load.
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