Abstract #4676
Measuring the effects of aging and gender on regional brain shear stiffness in healthy volunteers with MR Elastography
John Huston 1 , Arvin Arani 1 , Matthew C Murphy 1 , Kevin J Glaser 1 , Armando Manduca 2 , David S Lake 2 , Scott Kruse 1 , Clifford R Jack 1 , and Richard Ehman 1
1
Department of Radiology, Mayo Clinic,
Rochester, MN, United States,
2
Department
of Physiology and Biomedical Engineering, Mayo Clinic,
Rochester, MN, United States
Objective:
To
evaluate global and regional brain stiffness as a
function of age and gender using an improved magnetic
resonance elastography (MRE) approach.
Methods:
Full
volume 3-dimensional brain stiffness measurements were
acquired in a total of 45 healthy amyloid-negative,
cognitively normal subjects in the age range of 56-89
years.
Results:
Significant
negative correlations between age and brain stiffness
were observed in the cerebrum and the frontal, parietal,
occipital, and temporal lobes. A significant gender bias
was also observed in the occipital and temporal lobes.
Conclusions:
These
results suggest both age and gender impact stiffness in
certain regions of the brain.
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