Abstract #4677
Brain Iron Content and Smoking History in Healthy Older Individuals
Yosef A Berlow 1,2 , David L Lahna 3 , Daniel L Schwartz 4 , Randall L Woltjer 5 , Robin L Guariglia 3 , Lisa C. Silbert 3 , Jeffrey A Kaye 3 , and William D Rooney 1,2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Department
of Behavioral Neuroscience, Oregon Health & Science
University, Portland, Oregon, United States,
3
Department
of Neurology, Oregon Health & Science University,
Portland, Oregon, United States,
4
Department
of Psychiatry, Oregon Health & Science University,
Portland, Oregon, United States,
5
Department
of Pathology, Oregon Health & Science University,
Portland, Oregon, United States
Cigarette smoking has been demonstrated to significantly
alter systemic iron metabolism. This study utilized R
2
measurements
from MRI scans of 81 healthy elderly individuals to
investigate the relationship between smoking history and
MRI measures of brain iron content using a region of
interest analysis. Individuals with long-term smoking
histories were found to have increased R
2
values
in the caudate and putamen compared to aged-matched
nonsmokers and individuals with short-term smoking
histories. Increased R
2
values
were correlated with pack year history in the caudate.
These findings suggest that smoking cigarettes may
increase lifetime brain iron accumulation in these basal
ganglia structures.
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