Abstract #4678
Fornix shows a unique pattern of microstructural alteration and a relationship to network efficiency in healthy ageing
Rok Berlot 1,2 , Claudia Metzler-Baddeley 3 , Derek K Jones 3 , and Michael J O'Sullivan 1
1
Department of Clinical Neuroscience,
Institute of Psychiatry, King's College London, London,
United Kingdom,
2
Department
of Neurology, University Medical Centre Ljubljana,
Ljubljana, Slovenia,
3
Cardiff
University Brain Research Imaging Centre (CUBRIC),
School of Psychology, and the Neuroscience and Mental
Health Research Institute, Cardiff University, Cardiff,
United Kingdom
The link between age-related alterations in individual
tracts, whole white matter and network topology remains
unclear. In healthy elderly, we explored microstructural
variation in temporal association tracts, its
relationship to global white matter alterations and
structural network topology. Microstructural measures of
the fornix, both uncinate fasciculi and left
parahippocampal cingulum show significant relationships
with age, but only the fornix shows a relationship
independent of global white matter alterations. Network
global efficiency decreases with age, which is mediated
by fornix microstructure. The fornix demonstrates
age-related variation not shared with the rest of the
brain and a tight link to network topology.
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