Abstract #4679
Dyslipidemia and hypertension as cerebral blood flow predictors in the CRESCENDO cohort of elderly subjects.
Jeremy Deverdun 1,2 , Tasnime Akbaraly 3 , Frederic Ben Naim 4 , Alain Bonafe 5 , Adam Brickman 6 , Celine Charroud 3 , Stephane Chemouny 1 , Jeannette Fareh 7 , Nicolas Menjot de Champfleur 5 , Franois Molino 8 , Olivier Soulier 4 , Jason Steffener 6 , Florence Portet 3 , Yaakov Stern 6 , Karen Ritchie 3 , and Emmanuelle Le Bars 5
1
Intrasense, Montpellier, Herault, France,
2
Theoretical
Physics, Universite Montpellier 2, Montpellier, Herault,
France,
3
Unit
1061 : Neuropsychiatry: Epidemiological and clinical
research, Inserm, Herault, France,
4
Intrasense,
Herault, France,
5
Service
de neuroradiologie, CHU Gui de Chauliac, Montpellier,
Herault, France,
6
The
Taub Institute for Research on Alzheimer's Disease and
the Aging Brain, New York, United States,
7
SysDiag
UMR3145, CNRS, Herault, France,
8
Theoritical
Physics, Universite Montpellier 2, Montpellier, Herault,
France
Cerebral blood flow (CBF) is an important factor in
brain function. We to assess the link between quantified
gray matter CBF and epidemiological factors obtained 12
years before, on a large cohort of elderly subjects.
Mean and regional CBF were obtained from Pulsed Arterial
Spin Labeling sequence after correction for white matter
lesion and partial volume effect. Results exhibit
significant decrease in CBF in dyslipidemia and an
increase in hypertension. The regional analysis
highlights localization of these modifications in
posterior circulation territories (hypertension), and
regions of the anterior circulation (dyslipidemia).
Those two factors seems able to predict CBF variations.
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